Which drug reverses the effect of heparin

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Lopap, a prothrombin activator from Lonomia obliqua belonging to the lipocalin family: recombinant production, biochemical characterization and structure-function insights. Biochem J ; Assessment of recombinant factor VIIa as an antidote for bleeding induced in the rabbit by low molecular weight heparin.

J Thromb Haemost ; 1: A lipocalin sequence signature modulates cell survival. FEBS Lett ; Antithrombotic therapy for venous thromboembolic disease. In vivo characterization of Lopap, a prothrombin activator serine protease from the Lonomia obliqua caterpillar venom.

Effects of lopap on human endothelial cells and platelets. Haemostasis ; Mol Pharmacol ; Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers. Circulation ; Reversal of low-molecular-weight heparin-induced bleeding in patients with pre-existing hypercoagulable states with human recombinant activated factor VII concentrate.

Am J Hematol ; Wlian and L. Address for correspondence: A. E-mail: amchudzinski butantan. Received December 5, Accepted June 11, Available online June 29, Published September 3, All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Abrir menu Brasil. Brazilian Journal of Medical and Biological Research. Abrir menu.

Andrade L. Carrijo-Carvalho L. Peceguini L. Wlian A. Sato C. Luchiari E. Silva F. Maffei A. One patient receiving 2. There were no important hemodynamic effects of rPF4 administration at any dose used. Doses of 2. At lower doses, rPF4 neutralized the effects of heparin in most but not all patients. Abstract Introduction: Unfractionated heparin is a strongly anionic anticoagulant used extensively in medicine to prevent blood clotting.

Publication types Review.